Pharmaceutical / Biotech
Research & Development
Location: Indianapolis, IN
Ideal Candidate:
2+ to 5 years of experience
Management Experience Required – No
Education – BS or MS (This is not a PhD position)
Willingness to Travel – Occasionally
This cross functional position is an integral part of the Protein Optimization Characterization lab within the Protein Optimization Team of Biotechnology Discovery Research, which is responsible for generating, characterizing, and optimizing biotherapeutics from lead generation to lead optimization and preclinical development. We are seeking a motivated research associate with a BS or MS degree in biochemistry or related field that exhibits a broad analytical aptitude who can function in a highly collaborative environment performing analytical purification and biochemical characterization of proteins/peptides in a multidisciplinary team focusing on optimizing therapeutic properties of biotherapeutics.
KEY OBJECTIVES/DELIVERABLES:
The individual will perform mass spectrometry of proteins and peptides to support multiple drug discovery programs.
Additionally, they will perform appropriate protein sample preparation methods (e.g. in gel digestion, in solution digestion, protein/peptide separation on HPLC, etc.).
The individual will be responsible performing intact mass analysis, peptide mapping and LC MS/MS analysis.
Additionally the successful candidate will operate, maintain and troubleshoot liquid chromatography, mass spectrometers and auxiliary instrumentation.
The individual will also employ scientific background and communication skills to professionally support investigators by recommending sample preparation methods, advising in experimental design, and assisting in the analysis, evaluation, and interpretation of experimental results in conjunction with other staff within the Protein Optimization Team.
MINIMUM REQUIREMENTS:
A BS with more than two years of research experience or MS degree in protein biochemistry or related field is required.
This position requires knowledge and experience of HPLC, LC-MS, and LC MS/MS-based protein analysis and hands-on experience with purification and characterization of proteins
Characterize proteins by performing intact mass analysis, peptide mapping and LC MS/MS
Analytical biochemistry technique experience
